D. Iber[1,3], Z. Karimaddini[1,3], E. Unal[1,2], D. Menshykau[1,3]
D-BSSE, ETH Zurich, Basel, Switzerland
DBM University of Basel, Basel, Switzerland
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
Mathematical Modeling has a long history in developmental biology. Advances in experimental techniques and computational algorithms now permit the development of increasingly more realistic models of organogenesis. In particular, 3D geometries of developing organs have recently become available. In this paper, we show how to use image-based data for simulations of organogenesis in the COMSOL ...
Stochastic Diffusion of Calcium Ions Through a Nanopore in the Cell Membrane Created by Electroporation
O. Henao, V. Gómez, I. De La Pava, J. Sánchez 
Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia
We simulated the diffusion of calcium ions through a nanopore created in the cell membrane by electroporation, in presence and absence of the external electric field responsible of the membrane permeabilization. First we solved the set of coupled differential equations that describe the process of ionic diffusion in a 2D nanopore model using the AC/DC Module and the Transport of Diluted Species ...
M. Riou, C. Maedler, S. Erramilli, P. Mohanty
Boston University, Boston, MA, USA
Biosensors based on silicon nanowires are of great interest for ultrasensitive biomolecular recognition of disease specific markers for early stage diagnosis . However, there are limitations on the performance of these nanosensors in solutions at high ionic strength. This is because the electric field induced by the binding of biomolecule is partially screened on length-scales larger than the ...
Conductivity Estimation of Breast Cancer Using COMSOL® Modeling of Microwave Scattering and Frechet Mean Estimate of Covariance
A. Jeremic, E. Khoshrowshahli
Electrical & Computer Engineering, McMaster University, Hamilton, ON, Canada
Biomedical Engineering, McMaster University, Hamilton, ON, Canada
Breast cancer detection is one of the most important problems in health care and it is second most frequent cancer according to WHO. It is recommended that women over fifty or even younger in some cases do a screening test every two years. Besides clinical breast examination, there are number of imaging methods used for this purpose, such as mammography, ultrasound and MRI. Among them, ...
K. Cluff, L. Saeednia, H. Mehraein , R. Asmatulu
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Polymeric hydrogel is a promising class of drug delivery systems with the controlled release behavior in the body. In-situ forming hydrogels can be injected into the body as a fluid which forms a gel within the body tissue and improve the efficacy of the drugs. Various polymers have been used as in-situ hydrogel formulations. These polymeric formulations can form gels at body temperature while ...
S. D. Evans, J. S. Roth, M. R. Cheetham
University of Leeds, Leeds, UK
Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...
H. T. D. Grigg, T. H. Hanley, B. J. Gallacher
Newcastle University, Newcastle, Tyne and Wear, UK
This work enunciates the principles of SAW design from a physical perspective, examining the standard engineering modelling assumptions in some detail. An integral form analytical expression based on 2D elastic isotropic theory is validated against a COMSOL Multiphysics® simulation, corresponding to the traditional COM approach. Next, a COMSOL model of the full 3D problem, including anisotropy, ...
On the Influence of Cancellous Bone Structure upon the Electric Field Distribution of Electrostimulative Implants
U. Zimmermann, R.Bader, U. van Rienen
Institute of General Electrical Engineering, University of Rostock, Rostock, Germany
Department of Orthopaedics, University Medicine Rostock, Rostock, Germany
Since the 1980s, the accelerating effect of electromagnetic fields on bone regeneration is used to treat complicated fractures and bone diseases. At the University of Rostock, an electrostimulative hip revision system is developed, basing on the method of Kraus-Lechner. This method requires an electric fields between 5 and 70 V/m. The bone used for the simulations consisted of two homogenous ...
Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties
K. Cluff, H. Mehraein, G. Jayakumar
Bioengineering, Wichita State University, Wichita, KS, USA
Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...
Analysis of Heat Transfer in a Complex Three Dimensional Structure Fabricated by Additive Manufacturing
C. Settle, K. Hoshino
Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA
The goal of this study was to create a three dimensionally designed biomedical device with multiple functionalities and analyze its simulated heat transfer. The device would be fabricated through additive manufacturing; specifically electron beam melting (EBM). EBM has a feature size constraint of 1 mm (acceptable for this design) and is only capable of manufacturing titanium alloys ; a ...