A Virtual Pharmacokinetic Model Of A Human Eye

L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland
Publié en 2010

Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, absorption, distribution, metabolism, and excretion properties of a drug. Therefore, the aims of this study are: 1) to build a three dimensional pharmacokinetic model of a human eye; 2) to increase the number of known pharmacokinetic parameters in an eye by either experiments in vitro, or fitting the values obtained from the model to experimental ones; 3) to verify simulations with in-vivo imaging; 4) to study ocular iontophoresis.

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