Simulation Based Approach to Fluorescence Diffuse Optical Tomography

R. Singh, and I. Jose
BITS Pilani Goa Campus
Goa, India

Diffuse Optical Tomography (DOT) uses Near Infra-red (NIR) light to monitor physiological changes in internal organs. NIR light being less energetic in nature can be used for continuous monitoring of tumor infected biological tissue, neonatal brain and many such applications where high energy radiation can cause severe damage.

The forward problem of DOT, which involves obtaining of the radiance values of the light at the boundary of the specimen after irradiating it with NIR radiation, can be described by the Radiative Transfer Equation used with diffusion approximation. To model the phenomena COMSOL Multiphysics is used.

The inclusions inside the biological specimen for which the equations are being solved, can be fluorescent in nature. To allow the inclusion of fluorescent heterogeneities inside the biological media, PDE modes of COMSOL Multiphysics are used.