Consultez les proceedings de la Conference COMSOL 2020
Ionic Neuromodulation and Neurosensing Platform for In Vitro Studies
Overview We successfully simulated a template iontronic system for closed-loop neuromodulation and neurosensing. The model’s goal is to support the careful design of novel platforms for in-vitro micro-electrode-array sensors coupled to conductive polymer-based (CP) ionic actuators used ... En savoir plus
Optimizing Dielectrophoresis by Inducing Fluid Flow Using Droplet Oscillation
In regular biosensors, the detected bacteria have to be in drawn towards the sensing area. To increase the sensitivity of the biosensors, bacteria should be drawn towards the sensing area, which can be achieved by dielectrophoresis (DEP). DEP is a mechanism which is used to move ... En savoir plus
Optimization of the Oxygen Supply in Dynamic Cell Cultures
In many medical and biotechnological applications, cells are grown in dynamic cell cultures. Usually, the cells are cultivated on a scaffold with a complex channel structure through which the nutrient fluid flows and into which the cells can grow. However, a known problem is that the ... En savoir plus
Optimisation of Sensor Integration in Organ-on-Chip Platforms
Organs-on-Chips (OoCs) are microfluidics-based systems that aim to recapitulate the in-vivo behaviour of specific organs. Using a network of microfluidic channels, OoCs provide a biophysical and biochemical environment to sustain complex 2D and 3D cell cultures systems that recapitulate ... En savoir plus
3-D Modeling of Light, Flow, Mass and Heat Transfer in Coral Colonies
Corals are symbiotic marine organisms greatly dependent on the dynamic gradients of light, temperature and chemical species, all affected by the water flow in their surroundings. We developed a multiphysics modelling approach to simulate the microscale spatial distribution of light, ... En savoir plus
Acoustic-Mechanic Modeling of Polydimethylsiloxane in the MHz Regime for Metamaterials Applications
Polydimethylsiloxane (PDMS) is a biocompatible material widely used in biomedical applications such as implantable sensors. A realistic modeling of PDMS in acoustic-mechanic simulation is useful especially for medical applications which use ultrasonic waves as interrogation source. ... En savoir plus
Numerical Simulation-Driven Design of Nanophotonic Biosensors
Optical biosensors are powerful analytical tools for detecting and quantifying biological molecules and particles with high sensitivity and specificity. These devices operate on the principle of detecting changes in optical signals. For example, surface plasmon resonance (SPR) biosensors ... En savoir plus
Chemical Gradients, Carryover and Mixing in Fluidic Diagnostic Systems
Recent events underscore the importance of rapid diagnostic tests for detecting viruses such as the SARS-CoV-2 coronavirus or for screening cancer biomarkers. Many fluidic-based diagnostics applications require careful control of chemical and biological species concentrations. In this ... En savoir plus
Image based, geometry prescribed CFD of intra-cardiac flows on a dynamic heart phantom
Introduction: The current gold standard for measuring intra-cardiac blood flow is cardiac magnetic resonance (CMR) and Color-Doppler ultrasound [ref1]. The presented simulation pipeline extracts heart wall motion from medical imaging and simulates the intra-cardiac blood flow as an ... En savoir plus
FE-Simulation of PTCA Balloon Catheters
Within 40 years, percutaneous transluminal coronary angioplasty (PTCA) catheters evolved into the golden standard for treating coronary stenoses. However, navigating through tortuous vessel pathways and cracking highly calcified lesions is challenging. To minimize the risk of ... En savoir plus