C. Morgan, N. Kenkare, M. Williams, A. Peterson, and D. Williams
Alcon Eye Care Division of Novartis R&D, Duluth, GA
Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA
Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...
李娜 , 李江红 
研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法，但现有的头部损伤有限元模型基于尸体实验数据，且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息，实现深入到轴突水平有限元力学模型的建立，在有限元模拟中采用非线性超弹性力学模型，并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化，从而提高模型的稳定性和计算精度；将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证， 探索活体环境下碰撞损伤中脑轴突的损伤性变化，从而获得脑外伤损伤程度与力学因素之间的关系，为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...
M. Carfagna , A. Grillo ,
 Dipartimento di Scienze Matematiche, Politecnico di Torino, Italy
The numerical results of the unconfined compression test on a sample of Articular Cartilage (AC) are discussed. AC is modelled as a load-bearing, deformable, fiber-reinforced material filled with an interstitial fluid and comprising statistically oriented collagen fibers, chondrocytes, and a matrix of proteoglycans. A strain energy is assigned to characterize the mechanical behavior of the ...
Investigating the Loading Behaviour of Intact and Meniscectomy Knee Joints and the Impact on Surgical Decisions
M. S. Yeoman ,
 Continuum Blue Ltd., Cardiff, United Kingdom
Knee joints are often subject to high loads, which can lead to injury, malalignment, and the progression of osteoarthritis in patients. To better understand the behavior, and the effect of meniscal damage and different meniscectomy repair approaches, a 3D structural mechanics model of a patient specific knee was developed in COMSOL Multiphysics®. The model made use of the Structural Mechanics ...
Hemodynamic Therapy of Middle Cerebral Artery Vasospasm Guided by a Multiphase Model of Oxygen Transport
S. Conrad[1,2], P. Chittiboina, and B. Guthikonda
Department of Bioinformatics and Computational Biology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA
Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Cerebral vasospasm is a complication of subarachnoid hemorrhage and other neurosurgical emergencies that reduce blood flow to the brain. Part of the approach to management of vasospasm is to improve flow through the stenotic areas by reducing by decreasing blood viscosity and enhancing flow through the stenosis. To examine the interaction of these factors, we applied computational fluid ...
Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application
J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA
Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...
Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution
M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France
Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep tumors, the LITT procedure allows minimizing the impact on adjacent healthy structures. One of the effective methods to perform treatment planning for LITT is simulation. We used COMSOL Multiphysics to simulate the heat distribution and thermal ...
BD Medical - Medical Surgical Systems, Helsingborg, Sweden
Anders B Nilsson graduated M. Sc. in engineering physics from Lund University in Sweden. He has been working in the R&D department at BD Medical as principal engineer and project leader since 2005. He uses COMSOL for a wide range of functions, such as early concept development and qualification of products.
A. Gizzi, C. Cherubini, S. Migliori, and S. Filippi
Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy
Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...
D. Krapohl, S. Loeffler, A. Moser, and U.G.Hofmann
Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
Institute for Neurology, University of Luebeck, Lübeck, Germany
Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden
Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...