M. Blaziková, J. Malínský, D. Stanek, and P. Herman
Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
Institute of Experimental Medicine, Prague, Czech Republic
Institute of Molecular Genetics, Prague, Czech Republic
Small nuclear ribonucleoprotein particles (snRNPs) are essential supramolecular complexes involved in pre-mRNA splicing, the process of post-transcriptional RNA modifications. The particles undergo complex assembly steps inside the cell nucleus in a highly dynamic compartment called the Cajal body. We have previously shown that the free diffusion model does not fully describe the snRNP motion ...
Search for a Suitable Numerical Model for Electrical Stimulation: from the Electric Double Layer to Electrokinetics, Confrontation with Impedance Measurements
P. Pham, R. Scapolan, C. Rubeck, and F. Dupont
CEA-LETI-MINATEC, Grenoble, France
Electrical Stimulation is widely used today for Deep Brain Stimulation treatments and retinal prostheses. The Electrical Double Layer formed at the interface between the electrode surface and the extracellular medium is considered thru the linear Helmholtz model and the nonlinear more realistic modified Poisson Boltzmann model. These different models, solved using COMSOL Multiphysics, are ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
G. Long, D. Plescia, and P. Shires
Ethicon Endo-Surgery, Cincinnati, OH, USA
Thermal ablation of malignant tumors has been conducted in patients who are not candidates for surgery for more than ten years. Recently it has been shown that low energy DC pulses can cause cell necrosis. An undesirable characteristic of DC pulses in-vivo is the stimulation of skeletal muscle. The intensity of the contraction depends in part on the duration and height of the pulse. Through the ...
N. M. Sundaram, M. Sneha, A. Kandaswamy, R. Nithya
PSG College of Technology, Coimbatore, Tamil Nadu, India
Dr. N.G.P. Institute of Technology, Coimbatore, Tamil Nadu, India
The majority of elderly patients are subjected to hip bone replacement due to dislocation of bone, mechanical failure and infection. The life time of the implant varies from patient to patient depending on their daily physical activity. Once the implant fails, re-operation of hip bone replacement is performed. In United States, there are approximately 18 revision hip replacements performed for ...
A. Kahlig, J. Hansmann, H. Walles, and T. Hirth
University Stuttgart, Institute for Interfacial Engineering, Stuttgart, Germany
Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany
For the development of bioreactor systems, it is reasonable to develop working simulations, to avoid a lot \"trial-and-error\" experiments. Our research goal is the creation of functioning bone grafts for transplantation. Therefore stem cells get homogenously seeded into porous ceramic scaffolds. To evaluate the needed parameters, like perfusion pressure or the mechanical deformation of the ...
A. Candeo and F. Dughiero
Department Electrical Engineering, University of Padova, Padova, Italy
Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...
A. Grünbaum, S. Petersen, H.W. Pau, and U. van Rienen
IEF funded by DFG Research Training Group 1505/1 Welisa, University of Rostock, Rostock, Germany
Otolaryngology “Otto Körner”, University of Rostock, Rostock, Germany
Modeling of 2-5 μm thin membranes into a cochlea with a width of 2 cm is computationally. The paper is focused on two approximative methods used to overcome this problem and in addition a simple model challenging of a plate capacitor with a thin membrane of different thickness in-between is presented. The results of simulations with both thin layer approximation methods are compared with those ...
B. Jordan, and P. Müller
The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...
Pranay Goel received his B. Tech. in Engineering Physics from IIT Bombay, and MS and PhD in Physics from the University of Pittsburgh in 2003. He went on to two postodoctoral positions, the first at the Mathematical Biosciences Institute, The Ohio State University, and another at the Laboratory of Biological Modeling, The U.S. National Institutes of Health. He has been with IISER Pune since 2009, ...