Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...
3D COMSOL Multiphysics® Model of a Plate Heat Exchanger to Support a Laboratory Teaching Environment - new
N. Medeiros, W. Clark
Worcester Polytechnic Institute, Worcester, MA, USA
Chemical engineering students and practitioners need an understanding of fluid flow and heat transfer inside heat exchangers. Because the flow within plate heat exchangers is difficult to visualize, we developed COMSOL Multiphysics® simulations of plate heat exchangers for students to study alongside a physical heat exchanger in a laboratory setting. Simulative experiments allow students to ...
Stochastic Diffusion of Calcium Ions Through a Nanopore in the Cell Membrane Created by Electroporation - new
O. Henao, V. Gómez, I. De La Pava, J. Sánchez 
Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia
We simulated the diffusion of calcium ions through a nanopore created in the cell membrane by electroporation, in presence and absence of the external electric field responsible of the membrane permeabilization. First we solved the set of coupled differential equations that describe the process of ionic diffusion in a 2D nanopore model using the AC/DC Module and the Transport of Diluted Species ...
Submarine Gas Hydrate Reservoir Simulations - A Gas/Liquid Fluid Flow Model for Gas Hydrate Containing Sediments - new
S. Schlüter, T. Hennig, G. Janicki, G. Deerberg
Fraunhofer UMSICHT, Oberhausen, Germany
In the medium term, gas hydrate reservoirs in the subsea sediment are intended as deposits for carbon dioxide (CO2) from fossil fuel consumption. This idea is supported by the fact, that CO2 hydrates are more stable than methane hydrates at certain conditions. The potential of producing methane by depressurization and/or by injecting CO2 is studied in the frame of the research project SUGAR. ...
E. Laurenz, G. Füldner, L. Schnabel
Fraunhofer Institute for Solar Energy Systems (ISE), Freiburg, Germany
Adsorption heat exchangers (AdHXs) are important components in adsorption heat pumps and chillers, a primary energy efficient source of heating and cooling. Due to availability and established inexpensive manufacturing fin-and-tube type heat exchangers with beds of adsorption pellets in the finned space are widely used in state of the art products (Figure 1). For design and optimization the ...
S. Skoda, E. Robalinho, E. F. Cunha, M. Linardi
Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP, São Paulo, SP, Brazil
Universidade Nove de Julho - UNINOVE, São Paulo, SP, Brazil
The use of numerical techniques in PEM fuel cell sensoring represents an advantage of project engineering, reducing the costs and accelerating the manufacturing of prototypes. In this work some numerical responses are shown, relating to numerical sensoring of water and oxygen mole fractions at cathode of a 5 cm² of geometric area PEM fuel cell. The need to recognize a geometric figure of merit ...
O. Silva ,
 Amphos 21 Consulting S.L., Barcelona, Spain
Injection conditions of CO2 at the wellhead may play a major role on the flow behavior through the wellbore. The density and the injection rate reached at the bottomhole are key factors affecting the performance and efficiency of CO2 geological storage. In this work, a model of non-isothermal flow of CO2 in injection wells is developed using COMSOL Multiphysics® software and used to assess ...
H. Rana ,
 Loughborough University, United Kingdom
This paper presents the investigation into the phenomena during batch reactor vessel mixing comparing agitation equipment; the Rushton turbine and the Marine propeller; in the production of bioethanol by yeast fermentation. The key factors addressed in selecting equipment were fluid vector flow, energy dissipation resulting in shear damage to yeast cells, agitation power consumption, critical ...
ZINK, Imaging Inc.
In this work we have constructed a 2D COMSOL model for the drying of Latex. It is based on a prior 1D model of Kiil, but also includes the effects of a flowing air stream, which is necessary to remove the evaporated water vapor. The model illustrates several features of drying that are not accessible to the 1D model, in particular the a profile in the air/water interface that forms near the ...
C. Anandharamakrishnan, R. Gopirajah, and N. Chhanwal
Central Food Technological Research Institute
Freeze-drying is a popular method of producing shelf stable particulate products and is of particular value for drying thermally sensitive materials (volatiles and biological based), which can be heat damaged by higher temperature methods, such as spray-drying. Porous structures are formed by the creation of ice crystals during the freezing stage, which subsequently sublime during the drying ...