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Degradation of DNA in Plasma

Application ID: 1391

Biotechnology is a rapidly growing area in the pharmaceutical sciences. One example of a clinical application is gene therapy, where it is possible to produce proteins in vivo, using the body’s own mechanisms for protein production. Major issues in gene delivery involve the transport of plasmid DNA (pDNA) to target sites and the conversion between different forms of pDNA.

This example illustrates the use of the Parameter Estimation feature of the Reaction Engineering interface to find the rate constants of the three consecutive reactions involved in a typical DNA degradation process.

Ce modèle a été construit avec les éléments suivants:

Chemical Reaction Engineering Module

The combination of COMSOL® products required to model your application depends on the physics interfaces that define it. Particular physics interfaces may be common to several products (see the Specification Chart for more details). To determine the right combination of products for your project, you should evaluate all of your needs in light of each product\'s capabilities, consultation with the COMSOL Sales and Support teams, and the use of an evaluation license.