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Drug Release from a Biomaterial Matrix

Application ID: 786

In this example, drug-release from a biomaterial matrix to damaged cell tissue is modeled. Specifically, a nerve guide delivers a regenerating drug to damaged nerve ends. The model involves detailed drug release kinetics, with rate expressions handling drug dissociation/association reactions as well as matrix degradation by enzyme catalysis. The enzyme reaction is described by Michaelis-Menten kinetics.

The detailed reaction and transport description used in this model allows for investigation of many design parameters relevant to the bioengineering. For instance, the effect of matrix degradation on drug release is presented as a function of time and geometry.

Ce modèle a été construit avec les éléments suivants:

Chemical Reaction Engineering Module

The combination of COMSOL® products required to model your application depends on the physics interfaces that define it. Particular physics interfaces may be common to several products (see the Specification Chart for more details). To determine the right combination of products for your project, you should evaluate all of your needs in light of each product's capabilities, consultation with the COMSOL Sales and Support teams, and the use of an evaluation license.